![symphytum sp symphytum sp](https://ohioplants.org/wp-content/uploads/2012/05/Symphytum.jpg)
With respect to the inhibitory activity tested on various pharmacologically relevant enzymes, interesting anti-acetylcholinesterase (0.32 ± 0.03–3.32 ± 0.12 mg galanthamine equivalents/g), anti-butyrylcholinesterase (0.88 ± 0.06–5.85 ± 0.16 mg galanthamine equivalents/g) and anti-tyrosinase (21.84 ± 0.21–61.94 ± 2.86 mg kojic acid equivalents/g) properties were noticed. The evaluation of the antioxidant activity showed potent scavenging activity against synthetic radicals, cupric ion reducing (37.60 ± 0.15–436.26 ± 7.12 mg Trolox equivalents/g), ferric ion reducing (21.01 ± 0.74–229.99 ± 3.86 mg Trolox equivalents/g) and chelating capacity in general, the leaf extracts displayed superior antioxidant effects than the corresponding root extracts. The liquid chromatography hyphenated with tandem high-resolution mass spectrometry (LC–HRMS/MS)-based phytochemical profiling revealed a number of 29 distinct compounds, such as phenolic acids (e.g., caffeic acid, rosmarinic acid, globoidnan B, rabdosiin, globoidnan A), flavonoids (e.g., quercetin derivatives, luteolin, apigenin), pyrrolizidine alkaloids (e.g., intermedine– N -oxide, lycopsamine- N -oxide, symphytine- N -oxide), organic and oxygenated unsaturated fatty acids. ibericum varied between 10.53 ± 0.20 to 84.95 ± 0.60 mg gallic acid equivalents/g and between 0.81 ± 0.06 to 20.88 ± 0.29 mg rutin equivalents/g. Total phenolic and flavonoid content of extracts obtained from the leaves and roots of S. ibericum Steven, a perennial Boraginaceae plant distributed in the Northeastern Turkey and Caucasus region. However, to date there are no previous comprehensive phytochemical characterization and multi-biological evaluation of S.
![symphytum sp symphytum sp](http://www.fotoreiseberichte.de/ddorf/fotos/himmelgrhein/himmelgrhein003gr.jpg)
In the recent years, considerable research efforts were put into assessing the chemico-biological profile of unexploited Symphytum species, with the aim to extend the medicinal valences of the genus to new pharmacological applications. (comfrey, Boraginaceae) has a longstanding use as a remedy to alleviate the clinical symptomatology in arthritis, strains, contusions or sprains.